Health and medicine
Types of hormones
There are three major types of hormones. 1) Protein hormones (or polypeptide hormones) are made of chains of amino acids. An example is ADH (antidiuretic hormone) which decreases blood pressure. 2) Steroid hormones are derived from lipids. Reproductive hormones like testosterone and estrogen are steroid hormones. 3) Amine hormones are derived from amino acids. Epinephrine, which helps regulate the fight-or-flight response, is an amine hormone. . Created by Ryan Scott Patton.
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- At2:33, Why proteins and polypeptides are charged?(9 votes)
- Amino acids are often charged. sometimes the overall charge is neutral despite individual charges in the amino acid (zwitterion), but often the overall charge is not neutral. As these amino acids are linked to form polypeptides, their charges interact. This results in the overall molecule being charged. For more info, check out a great playlist on the topic by Tracy here:
- At9:58Ryan said that "all of our responses to the world around us are signaled by hormones." Aren't there quite a few processes that aren't signaled by hormones, like the way that most of the nervous system functions?(5 votes)
- Daniel, many neurotransmitters are also hormones! example Dopamine :)(13 votes)
- Just a tip! In the description of this video, where the types of hormones have been mapped out, ADH (anti-diuretic hormone) is mentioned to decrease blood pressure. ADH works by helping the body to retain/reabsorb it's water content, therefore increasing the volume of fluid within the vessels. This would lead to an increase in blood pressure, not a decrease.(9 votes)
- Haha noticed that too. It's still in the description. Thanks for your post.(0 votes)
- Explain why posterior pituitary hormone doesn't require releasing hormones.(1 vote)
- The posterior pituitary gland is simply an extension of the hypothalamus, it is heavily innervated by nerve endings that begin in the hypothalamus. So, since it's not entirely distinct from the hypothalamus, like the anterior pituitary gland is, it doesn't need releasing hormones.(7 votes)
- What are tropic hormones?(1 vote)
- Tropic hormones are hormones that have other endocrine glands as their target. Most tropic hormones are produced and secreted by the anterior pituitary.(5 votes)
- How are tyrosine and polypeptide hormones different from each other? I thought polypeptides were a strand of amino acids put together?(2 votes)
- I think tyrosine derived hormones are made up of a singular modified tyrosine amino acid. Whereas peptide hormones are composed of many amino acids linked together.(2 votes)
- why do we have polypeptide hormones at all why cant all hormones be steroid hormones so they can cross the cell membrane without the help of a secondary messenger(1 vote)
- Because there are many things you can do by using secondary messengers. For starters, they are much faster than changing nuclear expression (which many steroid hormones do). Moreover, it allows for very complex interactions between many different signalling systems, multiple hormones converging, or secondary messengers diverging from the same hormone in different contexts. For specifics, read up downstream signalling of Calcium in nerves or muscles or a large variety of tissues, it often has multiple interactions with many signalling systems and hormones(3 votes)
- If the pituitary gland is the master gland, how come the anterior pituitary gland has to release the tropic hormones?(2 votes)
- what are primary receptors?(2 votes)
- In primary receptors, the substrate that reacts to an external influence is embedded in the sensory neuron itself, which is directly (primarily) excited by the stimulus. In secondary receptors, additional specialized (receptive) cells are situated between the acting agent and the sensory neuron. The energy of external stimuli is transformed into nerve impulses in these cells.(1 vote)
- Are tyrosine derived hormones connecting with receptors located in or on a cell surface?(2 votes)
- Most interact with receptors on the cell's surface. However, thyroid hormone (T3 and T4) is an exception. These two hormones are tyrosine derivatives, but they are lipid soluble and bind to receptors within target cells.(1 vote)
OK. So when I introduced the endocrine system, I mentioned that hormones can be classified by where they function. And we talked about autocrine function and paracrine function and endocrine function. But maybe even more importantly, hormones can also be classified by structure. And I say more importantly because the structure of a hormone really determines how it works. And so that's what I want to talk about today, the three major types of hormones. And the first major type of hormones are proteins and polypeptides. And just as a refresher, proteins and polypeptides are made up of amino acids. And these amino acids are linked together with peptide bonds. And so many peptide bonds come together to form a polypeptide or a protein. And these proteins and polypeptides form most of our body's hormones. And these hormones can range from small to large. And to give you an example of what I mean by that, imagine it's three or so amino acids linked together forming a hormone. That would be a small polypeptide. In three amino acids, we're talking about a handful of atoms, maybe 20 or so atoms. And just as a frame of reference, a cell in your body, one cell, has on the order of a trillion atoms just inside that one cell. And there are 100 trillion cells in your body. And so we're talking about very, very, very small things. And they can range from these small collections of amino acids, all the way to hundreds and hundreds of amino acids. So they can get quite large. And the break point becomes right around 100. And that's where we shift from calling them polypeptides to proteins. And just like all proteins in your body that are going to be excreted, proteins and polypeptides hormones are made in the rough endoplasmic reticulum of the cell. And I'll shorten that to "RER." And they go from the rough endoplasmic reticulum to the Golgi apparatus. And from the Golgi apparatus, they're kind of repackaged into vesicles that can eventually be excreted from the cell. And because proteins and polypeptides are made of amino acids, they're typically charged. Which makes them water soluble, but it also gives them a really hard time crossing cell membranes. And so typically the receptors are located in or on a cell surface. And because the receptors are located in or on a cell surface and these protein and polypeptide hormones can't actually travel into the cell, what they do is they initiate a cascade effect of secondary messengers inside the cell. And I'm going to do an entire video about how that signaling cascade using secondary messengers actually works. But the main idea is that when these protein and polypeptide hormones bind to the cell surface, they initiate a response inside the cell. And we refer to that as a secondary messenger system. And so to save some time, I went ahead and drew in an example of a polypeptide hormone. And I'm going to kind of fade it in for us. And I want to show you on this drawing where the peptide bonds are because these peptide bonds really pull this class together and unify them. And so right in between the carbon and the nitrogen here and the carbon and the nitrogen here, I'll draw some arrows. These are the peptide bonds that I was referring too, these carbon-nitrogen bonds. And so they can be small and they can be large. But these links of amino acids that are used as chemical messengers to signal effects in the body are called proteins and polypeptides. And one example is insulin. Insulin is a relatively large hormone. And it's a protein hormone. OK. So we've got proteins and polypeptides. And then the second major type of hormones are steroids. And when we hear steroids, I don't know, the first thought that comes to my mind are a bunch of athletes getting in trouble with their regulating committees. But steroids are actually one of the major types of hormones used in our body to communicate. And so there are a lot of steroids in our body. But steroids come from lipids. And the major lipid that these steroids come from is cholesterol. And because they come from cholesterol, steroids have a really characteristic structure that all of them share. And so I went ahead and I predrew that as well. I'm going to fade that in. And so this is kind of the characteristic steroid backbone. And so you can see there are four ring structures here. And these rings are made of carbon atoms. And so there are three cyclohexane rings or six-membered carbon rings and one cyclopentane ring. And I'm going to label those A, B, C, and D. And what this characteristic structure, comes a really characteristic way of signaling a cell. And so unlike proteins and polypeptides, whose receptors are on the cell surface, steroids, because they're made of lipids, have a really easy time passing through the cell membrane. And their receptors are located inside the cell. And so steroids usually go all the way inside of the cell to signal the receptor as primary messengers. They're actually doing the signaling. And oftentime, their receptors are located either in the cytoplasm or all the way in the nucleus. But steroids typically go in, and their effect goes all the way down to the transcription and translation level of proteins. And so as primary messengers, they're going inside the cell, and they're effecting a change in that cell that's going to result in the transcription and the translation of new proteins and new products inside the cell. And I'm going to do a video on how these steroids actually affect the cell as well. But for now, I want you to be thinking of steroids as one of the major hormones that are in our body, not just a means for athletes getting an edge on the competition. And so some examples of big steroids in the body are those that come from the adrenal cortex, like cortisol and aldosterone, and those hormones that come from the gonads, like the sex hormones, testosterone and estrogen and progesterone. And so we've got steroids. And we've got proteins and polypeptides. And the third major type of hormones by structure are tyrosine derivatives. And tyrosine derivatives come from the amino acid tyrosine. And you might have caught on that I said these come from tyrosine, which is an amino acid. And I told you earlier that protein and polypeptide hormones are made of amino acids. And so you might ask yourself, why do these get their own major class if these are also made of an amino acid? And what makes them really special, A, is that they're made up of one amino acid. So one amino acid, tyrosine, is manipulated to make these hormones. And B, these hormones that are derived from tyrosine end up being able to sometimes act like proteins and polypeptides and sometimes act like steroids. So they really get their own class. And an example of tyrosine derivatives in the body are those that come from the thyroid gland, like T3 and T4, or triiodothyronine and thyroxine, that stimulate metabolism. And these tyrosine derivatives act really similarly to steroids. And then another example of tyrosine derivatives are catecholamines. And catecholamines are those hormones that are produced in the adrenal medulla that are involved in our fight or flight responses, like epinephrine and norepinephrine. And these thyrosine derivatives act really similarly to peptides by binding on the outside of the cell and releasing those secondary messengers inside the cell. And so the thyroid hormones that are tyrosine derivatives act like steroids. And the catecholamine tyrosine derivatives act like proteins and polypeptides. But it's important to remember that they form their own unique class because they're all derived from the amino acid tyrosine. And because I did it for proteins, and polypeptides, and steroids, I went ahead and I drew in what tyrosine looks like. So that's tyrosine. And that's the amino acid that this class of hormones is derived from. And so I know it's hard to make learning these types of hormones fun. But maybe at least we can let our minds blow up a little bit over the fact that the structure of these hormones dictates almost everything we think or do, from fear, to hunger, to urinating, and pushing babies out. All of our responses to the world around us are signaled by hormones.